This short film shows the impact of the CHAPAS trial on patient health and future possibilities of a small boy from Malawi.
This is a great video of a talk given at the Oxford Martin School by Professor Kevin Marsh.
It is time to revise the international Good Clinical Practices guidelines: recommendations from non-commercial North–South collaborative trialsby GHN Editors
The Good Clinical Practices (GCP) codes of the WHO and the International Conference of Harmonization set international standards for clinical research. But critics argue that they were written without consideration for the challenges faced in low and middle income countries (LMICs).
How the war in Syria is decimating human resources for health and health systems.
Preparing for and Executing a Randomised Controlled Trial of Podoconiosis Treatment in Northern Ethiopiaby Henok Negussie, Thomas Addissie, Adamu Addissie, Gail Davey
This study highlights the utility of rapid ethical assessment prior to clinical trials involving complex procedures and concepts.
Ebola: the race to find a cureby Sarah Boseley
Could scientists make history and change the way we deal with outbreaks?
Video of Professor Peter Horby, the University of Oxford, on how he and his team set up clinical trials in the heart of the Ebola outbreak.
Professor Lang talks about doing difficult trials in difficult places - including malaria and ebola trials.
Randomised controlled trials are the gold standard of health research evidence. Tension often exists between people wanting to use a new intervention, and the scientists who are generating evidence through a controlled evaluation study. One way that has emerged to balance this is the stepped wedge randomised controlled trial design.
Ethical, Social and Scientific Issues in Tropical Medicine Researchby Prof Sisira Siribaddana
Investigator initiated pragmatic clinical trials rather than explanatory clinical trials are needed. Collaborative trials should give something back to the community.
Professor Peter Piot, LSHTM, talks about Ebola and implications for Africa and understanding future epidemics at the Martin School, University of Oxford, 16th October 2014.
This guidance article aims to provide a fully comprehensive, pragmatic guide for researchers of all roles, but especially ethics reviewers, to explain the details of each type of ethics review. The article is available in English, Spanish, Portuguese and Chinese, and has been kindly provided by www.ctmagnifier.org.
Are students kidding with health research ethics? The case of HIV/AIDS research in Cameroonby Nchangwi S Munung, Godfrey B Tangwa, Chi P Che, Laurent Vidal, Odile Ouwe-Missi-Oukem-Boyer
Universities in Cameroon are playing an active part in HIV/AIDS research and much of this research is carried out by students, usually for the purpose of a dissertation/thesis. Student theses/dissertations present research findings in a much more comprehensive manner and have been described as the stepping-stone of a budding scientist's potential in becoming an independent researcher. It is therefore important to verify how students handle issues of research ethics.
Towards a more pragmatic approach to trial regulationby The Editors
Clinical trials in India continue to be in the news, unfortunately a fair bit being negative coverage.
Ethical issues in human genomics research in developing countriesby Jantina de Vries, Susan J Bull, Ogobara Doumbo, Muntaser Ibrahim, Odile Mercereau-Puijalon, Dominic Kwiatkowski, Michael Parker
Genome-wide association studies (GWAS) provide a powerful means of identifying genetic variants that play a role in common diseases. Such studies present important ethical challenges. An increasing number of GWAS are taking place in lower income countries and there is a pressing need to identify the particular ethical challenges arising in such contexts. In this paper, we draw upon the experiences of the MalariaGEN Consortium to identify specific ethical issues raised by such research in Africa, Asia and Oceania.